0207 Acute Total Sleep Deprivation Adversely Impacts Cardiovascular Measures across Long-Duration Intervals

Abstract Introduction For the first time, we comprehensively investigated effects of repeated exposures to baseline (BL), total sleep deprivation (TSD), and recovery (REC) phases at 2, 4, 8 months on cardiovascular (CV) measures. Methods We conducted a five-day experiment twice (at 2 4) in 4-month study (N=6 healthy adults; 3 females), similar three times 8) an 8-month (N=5 females). During these experiments, CV measures were collected via echocardiography or blood pressure monitor [systolic diastolic (SBP DBP)] assessment time points: 1) after two 8h bed (TIB) nights (BL); 2) night (TSD); 3) 8-10h TIB (REC). also once pre post study. Seated stroke volume (SV), cardiac index (CI), left ventricular ejection (LVET), SBP DBP, systemic vascular resistance (SVRI), mean arterial (MAP) collected. Data did not significantly differ between studies therefore pooled together for analysis (N=11). Repeated ANOVA post-hoc comparisons corrected multiple testing examined across all points. Results SV, CI, SVRI, LVET, SBP, but DBP MAP, showed significant changes time. SV increased with TSD compared pre-study, BL, post-study month 2. CI REC, SVRI decreased REC LVET BL In sample subset, 8. Conclusion Notably, 8, indicating sustained adverse effect long-duration exposure TSD. Overall, are reliable biomarkers assessing harmful long-term Support (if any) NASA grants NNX14AN49G 80NSSC20K0243 (NG)